FACULTY OF PHARMACY
B. Pharmacy 3/4 I Semester (Supplementary) Examination, April 2016
Subject Medicinal Chemistry I
Time 3 hours Max. Marks 70
Note: Answer all questions. All questions carry equal marks.
1 Explain physicochemical properties which influence biological activity. 7
Write the importance of bio-isosterism in drug design. 7
OR
Discuss about prodrug approach in drug design. 7
Give a note on drug distribution and protein binding. 3+4
2 Explain S.A.R. of Acetyl cholinesterase inhibitors. 6
Give the structure, synthesis and MoA of following 4+4
Dicyclomine HCl Carbachol
OR
Write a note on skeletal muscle relaxants. 6
Discuss S.A.R. of Adrenomimetics. 8
3 Classify anti arrhythmic drugs with suitable example and explain S.A.R. in
detail. 2+6
What are antihypertensives with examples? Give the synthesis of captopril
and clonidine.
OR
Write a note on Anti-hyperlipidemic agents. 5
Write a note on Cardiac glycosides and their mechanism of action. 5
Give the structure and synthesis of verapamil and dipyridamole. 2+2
4 Write a note on positive Inotropic agents. 5
Give the structure, synthesis and MoA of following
Amiloride Tolbutamide Propylthiouracil
OR
What are diuretics and give the classification with suitable examples. 1+2
Add a note on oral hypoglycemic agents. 5
write a short note on Immunomodulator drugs. 6
5 Write the structural activity relationship and MoA of proton pump inhibitors. 8
Give the synthesis and MoA of Ranitidine and chlorpheniramine. 3+3
OR
Discuss about coagulants and anti-coagulants. 2+4
Give the structure, synthesis and MoA of Diphenhydramine and Omeprazole. 4+4