FACULTY OF PHARMACY
B. Pharmacy III/IV II-Semester (Non-CBCS) (Backlog) Examination,
November 2018
Subject: Medicinal Chemistry I
Time: 3 Hours Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1. Write the importance of steric features of drugs 7
Explain the concept of pro and soft drug approach. 7
OR
Discuss in detail phase I reactions involved in the drug metabolism. 8
Explain about lipophilicity Solubility with examples 6
2. Write the pharmacological actions of Adrenaline and discuss the SAR of
adrenomimetics. 8
Give the structure and synthesis of following 3+3
Salbutamol ii) Isoproterenol
OR
Write a notes on following 7+7
Cholinergic blocking agents
ii) Skeletal muscle relaxants
3. Define anti-hypertensive and give the classification with examples. 5
Write the SAR of ACE inhibitors. 5
Give the structure and synthesis of clofibrate. 4
OR
Adda note on Antiplatelet drugs 7
Discuss about cardiotonic agents 7
4. Give the classification of oral hypoglycemic agents with examples. 4
Add a note on positive Inotrophic agents 6
Give the structure, uses and synthesis of Tolbutamide. 4
OR
Define and classify diurestics with examples. Write the MOA and SAR of carbonic
anhydrase inhibitors.
Add a note on Immuno suppressants. 6
Contd..2..
Library
G.Pulla Reddy College of Pharmacy
HyderabadOU 1701 OU 1701
Code No. 13043/Non-CBCS

5. Define and classify Anti-histaminic agents with examples.
Give the SAR of any two classes of H1 Anti histaminic. 7
List out the coagulation factors. 4
OR
Write the structure, synthesis, MOA and uses of following 5x4 14
Chlorpheniramine ii) Ranitidine
iii) Omeprazole iv) Warfarin