FACULTY OF PHARMACY
B. Pharmacy 3/4 I Semester (Main) Examination, October 2016
Subject: Medicinal chemistry I
Time: 3 Hours Max.Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 Write about bioisosterism and steric factors of drugs. 7
Explain the concept of pro and soft drug approach. 7
OR
Explain about the following terms with examples
Lipophilicity
ii) Partition coefficient
iii) Solubility
iv) Ionization
2 Explain S.A.R of adrenergic blocking agents. 8
Write the synthesis and mechanism of action of mecamylamine HCl and
Meprobamate. 6
OR
Give the structure, synthesis and mechanism of action of following: 7
Isoproterenol
ii) Salbutamol
Add a note on neuromuscular blocking agents. 7
3 Classify antihypertensive drugs with examples and SAR of ACE inhibitors. 9
Explain mechanism of action and uses of cardiac glycosides. 5
OR
Define and classify antihyperlipidemic drugs with examples and SAR of statins. 7
Give the synthesis of following
Diltiazem 3
ii) Captopril 4
4 Define and classify diuretics with examples. Write the mechanism of action and
therapeutic uses of carbonic anhydrase inhibitors. 7
Discuss the mechanism of action and limitations of oral hypoglycemic agents. 7
OR
Write a note on positive ionotropic agents. 7
Give a note on immuno suppressants and immuno stimulants. 7
5 Classify anti-histaminic agents. Discuss in detail mechanism of action of H1
antagonists. 14
OR
Give a note on proton pump inhibitors. 7
Discuss in detail about coagulants and anticoagulants. 7