FACULTY OF PHARMACY
B. Pharmacy 3/4 I-Semester (Suppl.) Examination, April 2017
Subject Medicinal Chemistry I
Time 3 Hours Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 Explain the importance of Bioisosterism in drug design.
Write about phase-I reactions of drug metabolism.
OR
Explain the importance of prodrug and soft drug approach in drug design.
How does plasma protein bound drug effect biological activity. Give appropriate
examples.
2 Classify Anticholinergic drugs with one example each with structure and chemical
name.
Give the structure and synthesis of following
Salbutamol Dicyclomine Carbachol
OR
Write the pharmacological actions of Adrenaline and discuss the SAR of
Adrenomimetics.
Write a note on skeletal muscle relaxants.
3 Write a note on digitalis glycosides.
Classify Anti-hyper lipidemic agents with examples.
Give the structure, synthesis and MOA of clonidine and verapamil.
OR
Add a note on vasodilators.
Write the structure, synthesis and MOA of following:
Clofibrate Captopril Isosorbide
4 Add a note on immune modulators.
Give the classification of oral hypoglycemic agents. Discuss the MoA and SAR
of Biguanides. Give the synthesis of Tolbutamide and Amrinone.
OR
Write about Anti thyroidal agents.
Give a short note on positive ionotropic agents.
5 Give the SAR of any two classes of H1 Antihistamines.
Write the synthesis and MoA of fallowing
Warfarin Ranitidine Citrizen
OR
Add a note on proton pump inhibitors.
Write the synthesis and MoA of following:
Omeprazole Diphenhydramine Chlorpheniramine