FACULTY OF PHARMACY
B. Pharmacy 3/4 I Semester (Main) Examination, November 2017
Subject Medicinal Chemistry I
Time 3 hours Max. Marks 70
Note Answer all questions. All questions carry equal marks.
1 What do you mean by prodrug approach in drug design? How is it achieved? 7
Write the importance of steric features of drugs. 7
OR
Define and give their significances for the following 4 x 3
Lipophilicity ii) Chelation iii) Partition coefficient
iv) Ionization
2 Explain the S.A.R. of -adrenergic blocking agents. 8
Give the synthesis and uses of Salbutamol ii) Mecamylamine HCl 3 x 2
OR
What are cholinergic drugs? Write the mode of action and S.A.R. 8
Outline the synthesis and uses of the following
Dicyclomine ii) Meprobamate 2 x 3
3 Classify Ani-hypertensives with examples and SAR of ACE inhibitors. 8
Write the synthesis and uses of clonidine and Dipyridamole. 3+3
OR
Give an account of 7+7
Cardiotonic drugs ii) Vasodilators
4 Add a note on positive inotropic agents. 8
Write the synthesis and uses of Amrinone ii) Tolbutamide 3+3
OR
Define and classify diabetes with examples. Write the MoA and uses of
carbonic antydrase inhibitors. 8
Give the synthesis and uses of following
Amiloride ii) Furosemide 6
5 Classify Anti-histamine agents. Give the SAR of any two classes of H1
Antihistaminics. 8
Write a note on proton pump inhibitors. 6
OR
Discuss in detail about coagulants and anticoagulants. 6
Write the synthesis and MoA of following 4+4
Omeprazole ii) Diphenhydramine