FACULTY OF PHARMACY
B. Pharmacy 3/4 I-Semester (Suppl.) Examination, April 2018
Subject Medicinal Chemistry I
Time 3 Hours Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 Discuss in detail the conjugation reactions involved in the drug metabolism.
Explain how the following physio-chemical properties influence the biological
action of a drug molecule
Ionization Hydrogen bonding
OR
Discuss with suitable examples the influence of protein binding on biological
activity.
Explain the importance of Bio-isosterism in drug design.
2 Explain the chemistry and mechanism of action of skeletal muscle
relaxants.
Give the structure and synthesis for the following:
Isoproterenol Moprobamate
OR
Classify ganglionic blocking agents with examples. Write the MoA and SAR.
Add a note on cholinergic blocking agents.
3 What are Anti-arrythmic drugs? Classify them with examples.
Give the structure, uses and MoA of following:
Verapamil Clofibrate Ticlopidine
Captopoil Dipyridamole
OR
Add a note on HMG CoA reductase inhibitors.
Give an account of cardiotonic drugs.
4 Write a note on the following:
Immuno suppressants
Hypoglycemic agents
OR
Outline the synthesis and uses of following:
Amrinone Acetazolamide Propylthio uracil
5 Discuss in detail about coagulants and anti-coagulants.
Write the SAR and MoA of proton pump inhibitors.
OR
Give the synthesis and MoA of
Warfarin Chlorpheniramine
Write the MoA and SAR of H2- receptor antagonists.