FACULTY OF PHARMACY
B. Pharmacy 3/4 I Semester (Suppl.) Examination, April 2016
Subject: Medicinal Chemistry I
Time: 3 Hours Max.Marks: 70
Note: Answer All questions. All questions carry equal marks.
1 Explain with examples the importance of partition-coefficient in relation to biological
activity of drugs. 7
What are prodrugs? How are they obtained? Mention their merits and demerits. 7
OR
Discuss with suitable examples the influence of steric features of drugs on biological
activity. 7
Discuss with examples the importance and significance of Phase-II reactions. 7
2 Classify ganglionic blocking agents with examples, write the mode of action, SAR
and outline the synthesis of Mecamylamine.
OR
Write short notes on:
Adrenergic blocking agents 7
ii) Cholinergic blocking agents 7
3 What are anti-arrhythmic agents? Classify them with examples, discuss the mode of
action and SAR.
Write the synthesis and specific uses of Nifedipine. 3
OR
Give an account of:
Cardiotonic drugs 7
ii) Vasodilators 7
4 Outline the synthesis and uses of Amiloride Tolbutamide
Propylthiouracil
OR
Write briefly on Thyroid agents Immunosuppressant. 7+7
5 Classify H2-receptor antagonists with examples, write the mode of action and SAR.
Outline the synthesis and uses of Ranitidine.
OR
Outline the synthesis and uses of Omeprazole Cetrizine
Diphenhydramine. Write a note on anticoagulants.