FACULTY OF PHARMACY
B. Pharmacy 3/4 I Semester (Main) Examination, November 2016
Subject: Medicinal Chemistry I
Time: 3 Hours Max.Marks: 70
Note: Answer All questions. All questions carry equal marks.
1 Explain with examples the importance of bioisosterism in relation to biological
activity. 7
What do you mean by soft drug approach in drug design? How is it achieved? 7
OR
Discuss with suitable examples the influence of protein binding on biological
activity. 7
Explain with examples the factors affecting the drug metabolism. 7
2 Classify adrenergic drugs with examples, wite the mode of action, SAR and
outline the synthesis of Atenolol.
OR
What are cholinergic drugs? Classify them with examples, discuss the mode of
action, therapeutic uses and outline the synthesis of dicyclomine.
3 What are antihypertensive agents? Classify them with examples, discuss
the mode of action and SAR of ACE inhibitors.
Write the synthesis and specific uses of clonidine. 3
OR
What are anti-hyperlipidemic agents? Classify them with examples,
write the mode of action and their SAR.
Write the synthesis and uses of Clofibrate and Diltiazem. 3+4
4 What are diuretics? Classify them with examples, discuss the mode of
action and SAR of thiazide diuretics. Outline the synthesis of Acetazolamide
and Hydrochlorthiazide.
OR
Classify oral hypoglycemic agents with examples, write their mode of action, SAR
and add a note on the current status of the management of NIDDM. Write the
synthesis and uses of Glyclizide.
5 Classify H1-receptor antagonists with examples, write the mode of action and SAR.
Outline the synthesis and uses of Chlorpheniramine and Cetrizine.
OR
Write a note on:
Anticoagulants 7
ii) Proton-pump inhibitors.