Master of Science II (Genetics)Examination: Oct Nov 2016
Semester III (New CBCS)
SLR No. Day
Date Time Subject Name Paper
No. Seat No.
SLR SQ
463
Wednesday
23/11/2016
02:30 PM
To
05:00 PM
Human Genetics
C
XII
Instructions: Section I is compulsory
From Section II attempt any four
Total Marks:70
Section I
Q.1 Rewrite the sentence after choosing the correct answer from the given
alternatives.
07
Mary Lyon proposed in 1961 that the Barry body was an inactive
Y chromosome B chromosome
X chromosome Polytene chromosome
mutations cause the complete or partial absence of normal
function
Gain-of-function Frame-shift
Non-sense Loss-of-function
Cystic fibrosis is an autosomal recessive disorder characterized by
Respiratory infections Incomplete digestion
Abnormal sweating All of these
When the SRY gene is lost or mutated in XY embryos, the indifferent gonad
becomes as
Testis Uterus
Ovary Prostate gland
has bridged the gap between cytogenetic diagnosis and
molecular diagnosis.
Widal Test PCR
ELISA Molecular cytogenetic testing
Simultaneous occurrence of testicular and ovarian tissue in a single gonad
called
Automixis Amphimixis
Ovotestis Somatogamy
describes a family tree diagram that shows a particular genetic
trait or disease has been inherited.
Cladogram Pedigree
Dendrogram Phylogenetics
Define the following terms.
Monogenic traits
Molecular pathology
Thalassemia
Anomalies of genital duct
Ultrasound
Genetic testing
Chimerism
Section II
Q.2 Explain in detail mitochondrial inheritance. 14
Q.3 Describe the complex polygenic syndrome with suitable example. 14
Q.4 Discuss genetic basis of male infertility. 14
Q.5 Answer any TWO of the following. 14
Explain in detail mechanism of sex linked inheritance
Describe in detail loss of function mutations in diseases.
Discuss in brief genetics basis on phenylketonuria
Q.6 Write short notes on any TWO of the following 14
Pre-implantation genetic diagnosis.
Recurrent pregnancy loss
Alzheimer's disease