Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharm. SEMESTER VI • EXAMINATION WINTER • 2016
Subject Code: 2260004 Date: 24-10-2016
Subject Name: Pharmaceutical Chemistry-VIII (Medicinal Chemistry II)
Time: 02.30 pm To 05.30 pm Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Draw structure and name the main heterocyclic ring present in the following drugs. Allopurinol ii) Naproxen iii) Ibuprofen iv) Halothane Amphetamine
vi) Chlorpromazine
06

Explain Various Forces involved in Drug-Receptor Interaction
05

Write with structure illustration metabolic biotransformation of any two of the following drugs Trimethoprim ii) Aspirin iii) Chloramphenicol
05
Q.2

What are Analgesics? Write SAR and mode of action of morphine
06

What is Cytochrome P-450? Explain its role and function in Xenobiotic Metabolism
05

Write synthesis of any one NSAID having one chiral centre.
05
Q.3

Discuss SAR of Tricyclic Antidepressant drugs with suitable example.
06

Write structure and IUPAC name of the following Fluoxetine ii) Imipramine
iii) Phenytoin iv) Methyl salicylate Paracetamol.
05

Abbreviate DMARD. Explain why Carbidopa is suggested with L-dopa in Parkinson's disease.
05
Q.4

Explain SAR of Barbiturates in detail.
06

Write synthesis of Lignocaine and discuss its mode of action
05

What is Alzheimer's disease? Discuss its cause and treatment.
05
Q.5

Classify and Write SAR of Anxiolytics.
06

Write a short note on Cognition Enhancers
05

Write synthesis of any two drugs Ibuprofen ii) Nimesulide iii)Carbamazepine
05
Q. 6

What is Psychoses? Explain SAR of Phenothiazines
06

Discuss Anti-Gout agents and their Mode of action.
05

Classify and Explain Hallucinogens in detail.
05
Q.7

Explain NSAIDs and comment how Opiod analgesics differ from NSAIDs.
06

Write a note on Antiparkinson drugs
05

Write synthesis of any two L-Dopa ii) Diclofenac iii) Thiopental sodium
05