Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharm. SEMESTER V • EXAMINATION WINTER • 2016
Subject Code: 2250004 Date: 30-11-2016
Subject Name: Pharmaceutical Chemistry-VII (Medicinal Chemistry
Time: 10:30 am 01:30 pm Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Discuss in detail how solubility and ionization affects biological activity of drug molecules.
06

Define drug therapy. Write a note on history of medicinal chemistry.
05

Give a brief account on Bioisosterism.
05
Q.2

Enlist various histamine receptors. Discuss neurochemistry of histamine.
06

What are antihistamines? Give SAR of ethylenediamines as antihistamines.
05

Give the synthesis of cetrizine and diphenhydramine.
05
Q.3

Discuss in detail about proton pump inhibitors along with its mechanism of action.
06

What are antisecretary agents? Discuss SAR of H2 receptor antagonist.
05

Outline the synthesis of ranitidine and omeprazole.
05
Q.4

Explain the following term with examples:
Antiemetics Mucolytics Laxatives
06

What is asthma? Write in detail about antiasthmatic agents.
05

Write a note on expectorants and antitussive agents.
05
Q.5

Classify sympathomimetic agents. Discuss SAR of adrenergic agonist.
06

What are eicosanoids? Explain the chemistry of prostaglandins.
05

Give the synthesis of albuterol and propanolol.
05
Q. 6

Enlist various cholinergic receptors. Discuss SAR of acetyl choline.
06

Write in detail about neurochemistry of catecholamines.
05

Eicosanoids approved for human clinical use.
05
Q.7

Write in brief about eicosanoid biosynthesis.
06

Explain neuromuscular blocking agent in detail.
05

What are diagnostic agents? Write a note on radiopharmaceuticals.
05