Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Pharm SEMESTER VI EXAMINATION SUMMER 2017
Subject Code: 2260004 Date: 05/05/2017
Subject Name: Pharmaceutical Chemistry -VIII (Medicinal Chemistry II)
Time: 10.30 am to 01.30 pm Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Explain Occupational theory and Induced fit theory of receptor in detail.
06

Write a brief note on factors affecting drug- receptor interaction.
05

Define Xenobiotics. Give importance of CYP-450 in drug metabolism.
05
Q.2

Enlist different pathways of drug metabolism. Describe any two conjugation reaction in drug metabolism giving specific examples.
06

Explain factors affecting drug metabolism in brief.
05

Define and classify CNS stimulants. Write a note on analeptics.
05
Q.3

Define Insomnia. Explain mechanism and structure activity relationship of Barbiturates derivatives.
06

Explain Structure activity relationship and mode of action of Tricyclic antidepressants.
05

Write a note on hallucinogens.
05
Q.4

Classify the drugs used in epilepsy in detail. Give synthesis of Phenytoin.
06

Define Anxiety. Write a note on Anxiolytic drugs.
05

Give synthesis of L-Dopa and Chlordiazepoxide.
05
Q.5

Define and classify local anesthetics. Explain the SAR of benzoic acid derivatives in detail.
06

What is Alzheimer's disease? Write note on drugs used in Alzheimer's disease.
05

Give synthesis and uses of Thiopental sodium and Fluoxetine.
05
Q. 6

What is Psyhoses? Give chemical classification of Antipsychotics and discuss the SAR of phenothiazine.
06

What is Parkinsons disease? Write a note on antiparkinson's agents.
05

Explain stages of anesthesia with classification of Inhalation anesthetics.
05
Q.7

What are NSAIDS? Give chemical classification of NSAIDS in detail.
06

Write a brief note on antigout agents.
05

Give synthesis of Diclofenac, Ibuprofen and Aspirin.
05