Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM SEMESTER EXAMINATION -WINTER 2018
Subject Code: 2260004 Date: 29/11/2018
Subject Name: Pharmaceutical Chemistry VIII (Medicinal Chemistry II)
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make Suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Define sedatives and hypnotics. Classify with examples. Discuss general method of synthesis of barbiturates.
06

Discuss SAR of local anesthetics having amide linkage in their structures.
05

What is Alzheimer's disease? Discuss its cause and treatment.
05
Q.2

What is Phase-II metabolism? How glucoronide conjugation helps to metabolized drug molecules. Explain with examples.
06

Write note on anti-gout drugs.
05

Write synthesis of Lignocaine and discuss its mode of action.
05
Q.3

Enlist and explain factors affecting drug-receptor interaction.
06

Explain Various Forces involved in Drug-Receptor Interaction
05

Write synthesis of Halothane ii Chlorpromazine
05
Q.4

Write synthesis of any two:
Ibuprofen
Nimesulide
Phenytoin
06

Classify and Explain Hallucinogens in detail.
05

Write synthesis of L-Dopa ii) Diclofenac
05
Q.5

Describe various forces involved in drug receptor interaction with examples.
06

Discuss SAR of Tricyclic Antidepressant drugs with suitable example.
05

Write synthesis of drugs xylocaine ii) Thiopental sodium
05
Q. 6

Define antipsychotic agents. Write detailed SAR of phenothiazines.
06

Explain different types of epilepsy. Classify epileptic agents with examples.
05

Write note on anti-anxiety agents.
05
Q.7

Write short notes on analeptic agents.
06

What are CNS dipressants. Write SAR of butyrophenones.
05

What is Cytochrome P-450? Explain its role and function in Xenobiotic Metabolism
05