Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharm. SEMESTER VI • EXAMINATION WINTER • 2016
Subject Code: 260004 Date: 24-10-2016
Subject Name: Pharmaceutical Chemistry-VIII (Medicinal Chemistry)
Time: 02.30 pm To 05.30 pm Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

What is xenobiotics? Describe Phase-I of Xenobiotic metabolism.
06

Describe factors affecting drug metabolism.
05

Write in detail Drug receptor interaction.
05
Q.2

Give synthesis of any two of the following Neostigmine Salbutamole
Dopamine
06

Describe SAR of Parasympathomimetics in detail.
05

Write a detail note on Antiparkinson's agents
05
Q.3

What are antidepressant drugs? Classify them in detail.
06

Write note on General anesthetics.
05

Write detail SAR of Barbiturate derivatives.
05
Q.4

What are Sedative and Hypnotics. Classify them in detail.
06

What is Alzheimer's disease? Discuss its treatment
05

Explain NSAIDs in detail.
05
Q.5

Give structure and use of the following
Chlorpromazine Paracetamole Morphine Diclofenac
carbamazepine Mefenamic acid
06

Discuss in detail about Sympatholytic agent.
05

Write a note on Anticholinesterase.
05
Q. 6

What are Opiod analgesics? Write mechanism of actions and Classification of Opiod analgesics.
06

Write a note on Neuromuscular Blocking agents.
05

Write detailed SAR of Parasympatholytics.
05
Q.7

Give synthetic scheme of any 2 of the following Lignocaine Allopurinole Adreanaline
06

Classify Local Anesthetics in detail.
05

Write a note on Antiepileptic agents.
05