C. S. (MAIN) EXAM, 2009,


MEDICAL SCIENCE

Paper I

Time Allowed Three Hours Maximum Marks:300

Each question is printed both in Hindi and in English.

Answers must be written in the medium specified in the Admission Certificate issued to you, which must be stated clearly on the cover of the answer-book in the space provided for the purpose. No marks will be given for the answers written in a medium other than that specified in the Admission Certificate.

Candidates should attempt Questions no. l and 5 which are compulsory, and any three of the remaining questions selecting at least one question from each Section.

The number of marks carried by each question is indicated at the end of the question.

Wherever required, the candidates may use coloured pencils for drawing sketches and diagrams in the answer book.

SECTION A

1. Answer any four of the following 15X4=60

Describe the blood supply, nerve supply and lymphatic drainage of the mammary gland.
Describe the gross anatomy of the thoraco-abdominal diaphragm. Mention the structures that pass through it.

Define consciousness. Which areas of the brain are mainly responsible for it What are the disturbances of consciousness

What are the differences between sympathetic and parasympathetic divisions of autonomic nervous system Why are parasympathetic nerves called nerves of tomorrow

In 1977, Rosalyn Yalow was awarded the Nobel Prize in Medicine for innovating an important technique which was considered a breakthrough in endocrinology. What is this technique Describe, briefly, the principle behind this technique.

2. Describe the development of the testis. 20

Explain its descent into the scrotal sac. 20

Add a note on its anomalies. 20

3. What are the functional divisions of cerebellum What will happen in lesion of each? 20

Discuss in short the morphology, functions and disorders of platelets. 20

Define menstrual cycle. What changes occur in the uterus during the cycle Name the common disorders of the menstrual cycle.

4. Define cardiac output. What factors maintain it 20 What happens to it during exercise and how? 20

There Is a precise molecular mechanism for initiating and terminating the synthesis of a polypeptide on ribosome. Explain in your own terms what happens if the termination has failed. 20

What IS real time polymerase chain reaction (rt. PCR) How does it differ from regular polymerase chain reaction How does this technique help to examine the single nucleotide polymorphism 20

SECTION B

5. Answer any four of the following 15x4=60

Explain the role of extracellular matrix in tissue repair.

Give the etiopathogenesis and morphology of membranoproliferative glomerulonephritis.

Describe the mechanism of action and adverse effects of drugs used to treat hypertension during pregnancy.

What are insulin analogues Describe their mechanism of action and advantages over regular insulin.

Describe how you will proceed to examine the "scene of crime in a case of hanging". Describe the differentiating features between hanging and strangulation on postmortem examination.

Describe the renal changes in diabetes mellitus. 15

Give the pathogenesis of corneal neoplasia. 15

Discuss briefly the following

Pathogenesis, laboratory diagnosis and prophylaxis of Dengue 8
Pathogenesis, laboratory diagnosis and prophylaxis of Candidiasis 7

Discuss laboratory diagnosis of malaria with special reference to new approaches to the diagnosis of malaria. 15

7. Describe the mechanism of action and adverse effects of Vasodilators used in Hypertensive Urgency/Emergency. 20

Enumerate the drugs used in Ascariasis and describe their mechanism of action and adverse effects. 20

Describe the mechanism of action and adverse effects of specific anti-cancer drugs. 20

8. Describe in brief about the causes of death from wounds. 20

Describe in brief about Dactylography. 20

Enumerate the drugs of abuse. How will you investigate a death due to poisoning by an overdose of drug of abuse 20

Note English version of the Instructions is printed on the front cover of this question paper.