CS MAIN 2015 MEDICAL SCIENCE (PAPER-I)


1. Answer all of the following (in about 150 words each)

Describe stomach under the following headings

Location

External features

(iii) Arterial supply

Clinical anatomy

Give the sequence of events that occurs during transmission of nerve impulse
through neuromuscular junction.

Differentiate between isometric and isotonic contraction in skeletal muscle.
Give one example of each type.

Describe the cervical part of the sympathetic chain.

Define ‘clearance’ of a substance by kidneys. Which clearance tests provide an
estimate of glomerular filtration rate Explain which of these is the test
of choice for assessment of GFR. What is eGFR?

2. What are the main important functions of pyridoxine (vitamin Explain.

What are the features of innate and acquired immunity? What is the
mechanism of action of immunoglobulins?

Describe the projection fibres of cerebrum.

3. Define ‘cardiac output’ and ‘cardiac index'. Describe the regulation of cardiac
output in the body.

Describe in detail about the origin and distribution of the sciatic nerve. Add a
note on its clinical importance.

Discuss briefly

Vitamin D resistant rickets

Chromium as a trace element

(iii) Role of plasma enzymes in evaluation of liver function

4. Describe tongue under the following subheadings

Mucous membrane and its nerve supply

Muscles, movements produced by them and their nerve supply

(iii) Lymphatic drainage

Clinical anatomy

Name the hormones involved in the regulation of blood glucose level. Discuss
the pathophysiology of diabetes mellitus.

Enumerate the hormones of posterior pituitary gland and describe their
actions in the body.

5.Answer all of the following (in about 150 words each)

Enumerate the chemical mediators of acute inflammation. Give their
mechanisms of action.

Define and classify hypersensitivity. Describe type I hypersensitivity.

Discuss the pharmacotherapy of gout. Describe the rationale of the use of
colchicine during acute attack of gout.

Enumerate the major etiological factors associated with carcinoma of lung.
Give the gross, microscopic features and spread of squamous cell carcinoma
lung.

A young person of 25 years has sustained smooth barrel shotgun firearm
injury on right side of chest. How will you establish on clinical examination the
entry wound and distance of fire?

6. Give etiopathogenesis of carcinoma cervix. What are the tests employed for
diagnosis of carcinoma cervix? Give the stages of carcinoma cervix.,

Discuss the pharmacology of calcium channel blockers. Enumerate the
reasons for combining beta blockers with amlodipine.

Discuss morphology and antigenic types of dengue virus. Describe the clinical
manifestations and laboratory diagnosis of dengue fever.

7. Write hypothetical medicolegal report of an injured person having sustained
stab wound penetrating lung deep on right side of chest.

A young female has consumed aluminium phosphide. Describe the symptoms,
signs and management of such poisoning.

Explain why

Frusemide should not be co-administered with aminoglycoside antibiotics

Sulfadoxine and pyrimethamine combination is used in the treatment of
malaria

(iii) Propranolol is contraindicated in chronic obstructive pulmonary disease

8. Write short notes on the following

Morphology, life cycle, pathogenicity and laboratory diagnosis of Giardia
lamblia

Pathogenesis and laboratory diagnosis of Candida albicans

What are the major and minor criteria of rheumatic fever? Give the pathology
and sequelae of rheumatic carditis.

Discuss briefly the mechanism of action, uses and side effects of the following

Sitagliptin

Clonidine

(iii) INH