B. Pharmacy 3/4 II-Semester (Main) Examination
Subject Physical Pharmacy-II
Time 3 Hours Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 Explain the solubility of solids in liquids. Write the factors (particle size,
temperature and other solids) influencing the same.
Explain the importance of solvents in solubility of Drugs.
OR
Discuss the preservative action of benzoic acid as it gets distributed between oil
and water (assuming no association molecules).
Write the effect of temperature and pressure on solubility of gases in liquids.
2 Discuss the accelerated stability testing of drugs with the help of various types of
graphs for solution dosage forms.
OR
Derive the first order kinetic equation.
What are various methods of determine the order of a reaction?
3 Define the importance of Zeta potential as a factor of stability indicator. With the
help of electric double layer diagram.
OR
Define and explain the importance of adsorption and discuss various types
adsorption isotherms.
4 Discuss the association of colloids and the phenomenon of CMC.
Define and write the importance of
True density Bulk density Granular density.
OR
Discuss the importance of particle size, size distribution and particle shape in
manufacturing of tablets.
5 Define and explain the importance of Thixotropy in pharmaceutical formulation.
Describe the measurement of viscosity with capillary viscometer.
OR
Define viscosity and explain various types flow with the help of flow diagram.
Describe the determination of viscosity with Cup and Bob viscometer.