FACULTY OF PHARMACY
B. Pharmacy 3/4 II Semester (Main) Examination, April 2017
Subject: Physical Pharmacy II
Time: 3 Hours Max.Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 Explain various factors influencing solubility of drugs. 9
ii) Write a note on effect of ionic dissociation on partition. 5
OR
Explain solubility of solids in liquids. 9
ii) Explain the relationship between solubility and partition coefficients. 5
2 Explain in detail the use of accelerated stability and stress testing in predicting shelf
life of drugs. 14
OR
What is the order of a reaction and how it can be determined. 5
Mention and explain the methods to prevent decomposition of medicinal agents. 9
3 Write about HLB classification and its importance. 7
Write about the application of ampliphiles. 7
OR
Explain surface and interfacial tension. 6
ii) Classify interfaces. Discuss the adsorption at solid interfaces. 8
4 Explain optical properties of colloids. 6
ii) Compare the properties of colloidal solutions. 8
OR
Discuss about the stability of colloid systems. 6
ii) Discuss about the particle size and size distribution and their applications in
formulation. 8
5 Discuss about Newtonian and non-Newtonian systems with the help of diagrams. 14
OR
Write a note on thixotropy and its role in pharmaceutical formulation. 9
ii) Describe any one method of determining viscosity. 5