FACULTY OF PHARMACY
B. Pharmacy 3/4 II Semester (Suppl.) Examination, November 2017
Subject Physical Pharmacy II
Time 3 hours Max. Marks 70
Note Answer all questions. All questions carry equal marks.
1 Explain how partition coefficients influence drug action. 3
ii) Explain various factors influencing solubility of gases in liquids. 11
OR
Explain distribution of solutes between immiscible solvents and write its
application in extraction. 4
ii) Explain the physicochemical principles involved in solubility of solutes in
liquids. 10
2 Derive the equation to compute rate and half life of first, order reactions. 7
ii) Explain the influence of solvents and catalysts on reaction velocity. 7
OR
Explain the general acid-base catalysis. 6
ii) Discuss the principles and methods of Accelerated stability testing. 8
3 Explain capillary rise method to measure viscosity. 4
ii) Explain electric properties of interfaces. 10
OR
Define surface free energy and spreading coefficients. 3
ii) Explain various physical principles involved in the study of adsorption at
liquid interfaces. 11
4 Explain lyophilic, lyophobic and association colloids. 6
ii) What are the various aspects in electrokinetic phenomena of colloids? 8
OR
Describe coacervation and cloud product phenomena. 6
ii) Write the pharmaceutical application of colloids. 8
5 Define Micelles and CMS. 3
ii) Write the applications of polymers in pharmacy. 11
OR
Define Newtonian and Non Newtonian systems. 4
ii) What is thixotropy? Explain with the help of rheorgrams. Write the
application of thixotropy in developing stable formulations. 10