FACULTY OF PHARMACY
B. Pharmacy 3/4 II-Semester (Main) Examination, April 2016
Subject Physical Pharmacy II
Time 3 Hours Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 Describe the effect of ionic dissociation and molecular association on
Partition.
State and explain Henry's law with applications.
OR
Explain about solubility of solids in liquids in detail.
Give a detailed note on partition coefficient and its applications.
2 Discuss the influence of temperature on drug decomposition with
Arrhenius equation.
What is a pseudo zero order reaction? Explain it with example.
OR
Explain about oxidative decomposition of drugs and write about the
preventive methods against oxidation.
Differentiate order of a reaction and molecularity of a reaction.
3 Define surface tension. Explain capillary rise method for the determination
of surface tension.
Discuss the factors influencing surface tension.
OR
What are adsorption isotherms? Explain about Freundlich isotherm and
Langmuir adsorption isotherms in solid gas adsorption.
What are surfactants? Write the applications of surface active agents.
4 Explain the electrical properties of colloids with the concept of donnan
membrane equilibrium.
Enlist the factors influencing the flow properties of powders.
OR
Write about the stability of lyophobic colloids with DLVO Theory.
How the particle size of a pharmaceutical substance is measured by
Andreasen apparatus?
5 Describe Newton's law of fluid flow. Explain different types of non
Newtonian flow behaviour with rheograms.
Explain about the factors influencing viscosity.
OR
What is thixotropy? Write about the applications of thixotropy and
measurement of thixotropy.
Explain plug flow and its prevention.
Explain bulges and spur with suitable example.