FACULTY OF PHARMACY
B. Pharmacy 3/4-Year II-Semester (Non-CBCS) (Backlog) Examination,
November 2018
Subject Physical Pharmacy II
Time 3 Hours Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 Define saturated solution? Describe with examples polar, nonpolar and semipolar
solvents? 7
Define distribution coefficient? Describe the effect of ionic dissociation and
molecular association on partition coefficient? 7
OR
Define complete or partial miscibility? Describe various factors controlling the
solubility of weak electrolytes? 7
Describe the influence of solvents and surfactants on solubility? 7
2 Describe the factors influencing solid state chemical kinetics? Describe methods
to stabilize pharmaceutical agents? 14
OR
Discuss the Accelerated stability testing in detail with various types of
graphs. 14
3 Describe surface free energy and surface tension? 7
Classify surface active agents and explain their importance in pharmacy? 7
OR
Explain spreading coefficientand and HLB value? 7
Differentiate between various types of monolayers and explain its methods
of characterization? 7
4 Describe various methods to determine the particle size? Discuss the role
and importance of particle shape? 14
OR
What are association colloids? Mention the mechanism of formation of micelles
with examples. 7
Explain the concept of DLVO theory with energy curves. 7
5 Define Newtonian, non-newtonian systems? 4
Explain non Newtonian system in detail? 10
OR
Classify polymers and its properties with examples? Explain in detail
pharmaceutical applications of polymers? 14