FACULTY OF PHARMACY
B. Pharmacy 4/4 I Semester (Main) Examination, November 2017
Subject Bio-Pharmaceutics and Pharmacokinetics
Time 3 hours Max. Marks 70
Note Answer all questions. All questions carry equal marks.
1 Define Absorption. Explain the various mechanisms of drug absorption. 14
OR
Write about different physicochemical properties which affect the absorption. 10
Explain the application of pH partition theory in predicting the drug absorption. 4
2 What is the influence of various disease states on plasma protein level and
drug binding? 7
Briefly describe the process of drug distribution in the body and enumerate
the factors affecting it. 7
OR
Name the physiological barriers for drug distribution. With the help of suitable
diagrams explain them. 9
How the organ size and perfusion rate influence the drug distribution? 5
3 Explain phase-I and phase-II biotransformation reactions. 14
OR
Explain about non renal routes of excretion of drug and factors influencing
them. 10
Write factors influencing the metabolism of drugs. 4
4 Explain the methods of adjusting the dose and dosage regimen in patients
with liver diseases. 8
Write about zero order reaction and zero order half life with graphic
illustration. 3
Derive the equation for calculation of biological half life. 3
OR
Write in detail about pharmacokinetic drug interactions and its significance in
combination therapy. 7
Discuss the methods of dose adjustment in renal impairment. 7
5 Plasma samples from a patient were collected after an oral dose of 10 mg of a
new benzodiazepine solution as follows
Time 0.25 0.5 0.75 1 2 4 6 10 14 20
Plasma
concentration

2.85 5.43 7.75 9.84 16.2 22.1 23.0 19.0 13.9 7.97
From the above data calculate all possible pharmacokinetic parameters
assuming the drug follow one compartment open model. The percentage of the
drug absorbed is 80%. 14
OR
Discuss in detail compartment model for intravenous infusion. 7
Explain the method of residuals for calculation of absorption rate constant. 7