FACULTY OF PHARMACY
Pharm. D YDC) IV Year (Instant) Examination, March 2018
Subject: Biopharmaceutics and Pharmacokinetics
Time: 3 Hours Max. Marks: 70
Note: Answer all questions from Part A and answer any five questions from Part-B.
PART A (10 x 2 20 Marks)
1 Give the specific characteristics of carrier mediated transport
2 Why intravenous administration of thiopental causes a quick onset of action and a
Rapid termination of action.
3 Differentiate excretion rate method and sigma minus method.
4 Give a brief account on principle of superposition.
5 Why are phase-I reactions called as functionalisation reactions?
6 Mention different Pharmacodynamic parameters.
7 Give a brief note on clearance of drugs.
8 Write about statistical moment theory.
9 What is the rate limiting step in bioavailability?
10 Write about Enzyme induction.
PART B x 10 50 Marks)
11 Explain briefly about the bioavailability study protocol.
12 Explain in detail about the dosage form factors affecting drug absorption.
13 Write the causes of nonlinearity.
Derive the kinetics of protein binding.
14 Write about different non-renal routes of excretion.
15 (a)Derive the equation for I.V infusion unchanged drug in Blood/Plasma following one
compartment model.
A patient is given an antibiotic having t1/2 of hrs by constant IV infusion at a rate of
3 mg/hr. At the end of 36 hrs, the plasma drug concentration is 2.2mg/L. Calculate
the total body clearance(L/t) for this antibiotic. What is the volume of distribution of
drug
16 Write a detailed note on pharmacokinetic models.
17 Give a brief account on phase-I reactions.
18 Derive the equation for determination of ka by Wagner-Helson method.