FACULTY OF PHARMACY
Pharm. D YDC) IV-Year (Main) Examination, July 2017
Subject Bio Pharmaceutics and Pharmacokinetics
Time 3 Hours Max. Marks: 70
Note: Answer all questions from Part A and answer any five questions from Part-B.
PART A (10 x 2 20 Marks)
1 Define bioavailability and write any two objectives.
2 List the factors that influence the gastric emptying role.
3 State the pH partition hypothesis and its assumptions.
4 Why is in-vivo drug dissolution always faster than in vitro dissolution?
5 What are the characteristics of microsomal enzymes?
6 Mention various factors influencing renal excretion of drugs.
7 Write a short note on flip-flop phenomenon.
8 What do you mean by principle of superposition?
9 Why the drugs are administered in multiple doses?
10 What are the assumptions made in developing for the one compartment model?
PART B x 10 50 Marks)
11 Explain briefly physiological barriers for the dissolution of drugs.
Write the concept of clearance.
12 What is statistical moment theory?
Derive Michalis Menton equation and give its importance.
13 Write a note on drug accumulation in multiple dosing.
How do you determine steady state maximum and minimum concentrations of drug
following multiple oral doses?
14 Explain the mechanism of drug absorption from GIT.
15 Explain briefly protocols and methods of assessment of Bioavailability.
16 Explain conjugation reactions for elimination of drugs with suitable examples.
17 Write a detailed note on compartment model.
18 A 59 kg male received 2 mg kg of an antibiotic orally. The plasma concentration vs time
data is obtained. Assume that the drug follows one compartment open model and is
completely absorbed. Calculate all possible parameters.
Time 0.25 0.5 0.75 1.0 1.5 2.0 2.5 3.0 4.0 6.0 8.0 12 18 24
Plasma conc. 2.2 3.8 5 5.8 6.8 7.1 7.1 6.9 6.2 4.8 3.5 1.9 0.8 0.3