FACULTY OF PHARMACY
Pharm D IV-Year (Main Backlog) Examination, July 2018
Subject: Biopharmaceutics Pharmacokinetics
Time: 3 Hours Max.Marks: 70
Note: Answer all questions from Part A. Any Five questions from Part B.
PART A (10x2 20 Marks)
1 Define absorption window and write its significance.
2 Renal excretion of penicillin is unaffected by protein drug binding. Why?
3 Differentiate between absolute and relative bioavailability.
4 In comparison to mammillary model the caternary model is less useful. Why?
5 List the factors that influence the gastric emptying rate.
6 Write a note on drug accumulation in multiple dosing.
7 What are the assumptions made in developing for a one compartment model?
8 Explain Fick's law of diffusion.
9 What is flip-flop phenomenon and when is observed.
10 What do you mean by principle of superposition?
PART B (50 Marks)
11 Describe influence of drug dissolution, polymorphism and compression forces in
drug absorption with suitable examples.
12 Explain various factors affecting distribution of drugs.
13 Explain the kinetics of drug absorption from plasma concentration data following oral
dose by using Wapner-Nelson method.
14 Write a note on non-linear pharmacokinetics. 3
Derive Michaelis-Menton equation and estimation of Km and Vmax. 7
15 What is statistical moment theory and MRT? Explain briefly about various
physiological pharmacokinetic models.
16 Explain briefly protocols and methods of assessment of bioavailability. 10
17 Write a detailed note on compartment model. 10
18 Why the drugs are administered in multiple doses. 2
How do you determine steady state maximum and minimum concentrations of
drug following multiple oral doses? 8