FACULTY OF PHARMACY
Pharm. D. YDC) IV Year (Instant) Examination, January 2018
Subject: Biopharmaceutics and Pharmacokinetics
Time: 3 Hours Max.Marks: 70
Note: Answer all questions from Part A. Answer any five questions from Part B.
PART A (10 x 2 20 Marks)
1 What is the major mechanism of absorption of most drugs? What is the driving
force for such a process? 2
2 What are soft drugs? Why are they considered safe and have short half life? 2
3 Brief notes on plateau principle? 2
4 Why is HSA considered a versatile protein for drug binding? 2
5 Define absolute and relative bioavailability. What is the basic difference between
two? 2
6 Brief notes on limitations of multi-compartmental analysis. 2
7 What is flip-flop phenomen and when is it observed. 2
8 Write notes on MRT. 2
9 What is the main reason for giving a drug by slow IV infusion? 2
10 Define GFR and factors affecting renal excretion. 2
PART B (5x10 50 Marks)
11 Discuss the physicochemical properties of drugs affecting GI absorption with
suitable examples. 10
12 Describe the pharmacokinetic method of estimating bioavailability using plasma
sample and urine sample. 10
13 Give possible reasons for reduction in dose of drug in elder patients. 5
Write notes on randomized block design. 5
14 Explain the Michaleins Menten kinetics and method to determine Km and Vmax. 10
15 Explain the physiologic pharmacokinetic models. 10
16 A 70 Kg patient is to be given oubain by I.V. infusion. The drug has a half life of 22
hr, apparent Vd 15.7 litres and the desired steady-state plasma concentration is
0.0002 mcg/ml. Assuming one compartment kinetics calculate time required to
reach 90% Css Infusion rate to achieve the desired Css loading dose to
attain Css rapidly concentration of drug in plasma after 48 hrs from the start of
infusion. 10
17 Explain the phenomen of drug accumulation. 10
18 Write notes on intrinsic dissolution rate? How is it determined? 5
Write notes on first pass metabolism. 5