FACULTY OF PHARMACY
Pharm. D. YDC) IV Year (Main) Examination, Sept 2017
Subject Bio-Pharmaceutics and Pharmacokinetics
Time 3 hours Max. Marks 70
Note: Answer all questions from Section-A and answer any Five questions
from Section-B.
Section A (10 x 2 20 Marks)
1. Differentiate the terms biopharmaceutics and pharmacokinetics. 2
2. Vitamin B complex preparations are advised to be taken after meals. Explain. 2
3. Amorphous form has greater solubility as compared to that of crystalline form, Why? 2
4. Define bioavailability. List two of its applications. 2
5. List the reasons for the failure of IVIVC Intravenous catheters. 2
6. Describe the term with the help of one-compartment open model. 2
7. Define volume of distribution and give its significance. 2
8. Drug-protein binding increases renal excretion of drug. True/False. Explain. 2
9. Explain the terms 'biotransformation' and 'detoxification'. 2
10.Give two reasons for observing nonlinear pharmacokinetics at high doses of drugs. 2
Section B x 10 50 Marks)
11. Explain in detail on the objectives and considerations in bioavailability study. 10
12.a) Describe the significance of non-renal excretion of drugs.
Write the importance of conjugation reactions. 7+3
13. Describe two methods for determining elimination half life of a drug in one compartment
model from urine analysis. 10
14. Write the characteristics of drug absorption mechanisms in GIT with suitable
examples. 10
15.a) Explain the importance of oxidative reactions in metabolism. Describe the role
of cytochrome P450 in oxidation-reduction cycle.
Write the significance of AUC. 7+3
16. Describe saturation kinetics with reasons, implications and examples. 10
17.a) Describe the role of physiological barriers for distribution of drugs.
Explain the role of polymorphism on drug absorption. 6+4
18. A dose of 325mg of a new drug injected Intra venously to healthy volunteer and
the following data was obtained. 10
Time 2 4 6 8 10 12 16 20
Plasma conc'n 18.3 10.1 5.8 3.3 1.8 1 0.31 0.12
Calculate various pharmacokinetic parameters.