FACULTY OF PHARMACY
B. Pharmacy IV Year II Semester (Main) Examination
Subject: Pharmacoinformatics
Time: 3 Hours Max.Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 Write about data mining and Knowledge Discovery in Databases (KDD).
Write about Database Architecture and Codd's rules?
OR
What is database normalization? Discuss about different types of normalization.
Write about bibliographic databases and library catalogs.
2 What is sequence alignment? Explain Needleman Wunsch algorithm and Smith
Waterman algorithm for sequence alignment?
OR
Write a note on database querying, key work searching and search machines?
Write the applications of HMM.
3 Classify the drug information resources available. Give their merits and demerits
with examples.
What are databases useful for emergency treatment of poisoning?
OR
Write a brief note on coding of information and barcodes.
What is pharmacy automation? Write its importance in medication distribution and
inventory control.
4 What is DNA sequencing? Write and explain methods of sequencing.
Write short note on cosmid libraries and BAC libraries.
OR
Write a note on protein sequence databanks
Swissport ii) PIR iii) Interpro
5 What is drug design? Write about Free-Wilson and Hansch analysis for QSAR.
Write a brief note on docking.
OR
Write a brief note on theories of drug activity and drug-receptor interactions.
Write methods and applications of energy minimization.