B. Pharmacy 2/4 II-Semester (Main) Examination, April 2017
Subject Pharmaceutical Organic Chemistry II
Time 3 Hours Max. Marks: 70
Note: Answer All questions. All questions carry equal marks.
1 Write the mechanism of sulphonation in benzene.
Explain the nucleophilic substitution in Halobenzene.
OR
Explain the Riemen tiemann reaction of phenols.
Write the structure and electrophilic of substitution reacitons of Anthracene.
2 Write a note on sequence rule.
Discuss cis-trans isomerism.
OR
Write a brief note on concept of stereospecifics.
Discuss conformational isomerism.
3 Write a note on Fischer Indole synthesis.
Discuss the electrophilic aromatic substitution reactions of pyridine.
OR
Write any two methods of synthesis of thiophene.
Discuss the oxidation reactions of quinoline and isoquinoline.
Write the structure and specific uses two medicinally important compounds
representing each of following heterocyclic systems.
Quinoline Furan
4 Explain any two methods of preparation of isoxazole and pyrazole.
Write the drug structure and nomencluature following heterocyclic
compounds.
Benzofuran Oxazine Triazine Phenan
OR
Explain any two methods of preparation of benzimidazole.
Write the structure and system of numbering of the following heterocyclics
with two examples of medicinally important compounds.
Benzopyran Dioxan Cepham
5 Write two applications of each of the following
Lead tetra acetate Sodium periodate
Describe the mechanisms of following reactions.
Arndt Eistert synthesis Beckmann Rearrangement
OR
Write two applications of each of the following:
N-Bromosuccinimide Peachloric acid
Describe the mechanism of following reactions.
Hoffman's hypobromite MPV reduction