FACULTY OF PHARMACY
B. Pharmacy 2/4 II-Semester (Supplementary) Examination, November 2017
Subject Pharmaceutical Organic Chemistry II
Time 3 Hours Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 Explain the mechanism for Nitration and Halogenation of benzenes.
What are polynuclear aromatic compounds? Discuss in detail the reactions of
Napthalene.
OR
Explain in detail the effect of substitutent on orientation of mono substituted
aromatic compounds.
Explain in detail Huckel 4n 2 rule and aromaticity.
2 Write a note on conformational isomerism.
Write the sequence rules to determine R and S configuration.
OR
Explain optical isomers with examples.
Explain the following terms
Plane polarized light Diastereomers
Mesostructures Enantiomer
3 Outline the method of preparation and two important reactions of the
following:
Isoquinoline Acridine
Give two examples of medicinally important compounds representing each
of the following heterocyclic systems.
Furan Pyrrole
OR
Explain why Electrophilic substitution takes place at 3rd position in pyridine.
Compare the aromaticity of pyrrole, Furan and thiophene.
(iii)Discuss the reactions of pyridine
4 Explain any two methods of preparation of pyrozole and oxazole.
Write the ring structure and Nomenclature of following Heterocyclic
compounds.
Cinnoline Oxazine Triazine Tetrazole
OR
Write the characteristic reactions of thiazole and pyrazine.
Discuss any two methods of preparation and reactions of Imidazole.
5 Write two applications for each of the following:
Lithium Aluminium Lead Tetra Acetate N-Bromosuccinimide
Describe mechanism of following reaction.
Oppenneur oxidation Birch reduction
OR
Describe mechanism of following reaction.
Fries migration MPV reduction
Write the applications of each of the following (any two applications).
Sod. Periodate Selenium oxide Perchloric acid