FACULTY OF PHARMACY
B. Pharmacy 2/4 II Semester (Suppl) Examination, April 2018
Subject: Pharmaceutical Organic Chemistry-II
Time: 3 Hours Max. Marks: 70
Note: Answer All Questions. All Questions carry Equal Marks.
1. Explain the mechanism of Nitration and Halogenation in Benzene. 6
What are Poly nuclear aromatic compounds? Discuss in detail the reactions of
Naphthalene 8
OR
Explain in detail the Effect of substituent on orientation of mono substituted aromatic
compounds. 8
Explain in detail 4n+2 rule and aromaticity. 6
Explain Optical isomerism with examples 6
Explain the following terms: Plane polarized light ii) Diastereomers
iii) Meso structures iv) Enantiomers 8
OR
Write a brief note on Conformational isomerism. 6
Explain sequence rules to determine R and S configuration. 8
Define Heterocyclic compounds and Explain systematic nomenclature to name
heterocyclic compounds with four examples. 8
Write the structure and specific uses of drug compounds containing
Pyrrole ii) Furan 6
OR
Discuss the Electrophillic aromatic substitution reactions of thiophene 8
Outline the method of preparation and important reactions of 6
Quinoline ii) Isoquinoline.
Outline the method of preparation and important reactions of Benzimidazole. 8
Write the structure and specific uses of drug compounds containing 6
Thiazole ii) Oxazole
OR
Outline the method of preparation and chemical reactions of Pyrazole. 8
Write the Structure and specific uses of drug compounds containing 6
Phenam ii) Cepham
Write two applications for each of the following 6
LAH ii) Lead tetra acetate iii) N-Bromosucinamide
Describe mechanism of following reaction 8
Oppenneur oxidation ii) Birch reduction
OR
Describe mechanism of following reaction 8
Fries migration ii) MPV reduction
Write two applications for each of the following 6
Sodium periodate ii) Selenium oxide iii) Perchloric acid