FACULTY OF PHARMACY
B. Pharmacy 2/4 II Semester (Suppl.) Examination, November 2017
Subject Pharmaceutical Organic Chemistry-II
Time 3 hours Max. Marks 70
Note Answer all questions. All questions carry equal marks.
1 Explain the mechanism of Nitration and Halogenation in Benzene. 6
What are polynuclear aromatic compounds? Discuss in detail the reactions of
Naphthalene. 8
OR
Explain in detail the effect of substituent on orientation of mono substituted
aromatic compounds 8
Explain in detail 4n+2 rule and aromaticity. 6
2 Explain optical isomerism with examples. 6
Explain the following terms
Plane polarized light ii) Diasteromers iii) Meso compounds
iv) Enantimers 8
OR
Write a brief note on conformational isomerism. 6
Explain sequence rules to determine R and S configuration. 8
3 Define Heterocyclic compounds and explain systematic nomenclature to
name heterocyclic compounds with four examples. 6
Explain why electrophillic aromatic substitution takes place at 3rd position in
pyridine. 4
Write the structure and specific uses of drug compounds containing
Pyrrole ii) Furan 4
OR
Discuss the electrophillic aromatic substitution reactions of thiophene. 8
Outline the method of preparation and important reactions of
Quinoline ii) Isoquinoline 6
4 Outline the method of preparation and important reactions of Benzimidazole. 8
Write the structure and specific uses of drug compounds containing
Thiazole ii) Diazine iii) Oxazole 6
OR
Outline the method of preparation and chemical reactions of Pyrazole. 8
Write the structure and specific uses of drug compounds containing
Triazole ii) Phenam iii) Cepham 6
5 Write two applications for each of the following
LAH ii) Lead tetraacetate iii) N-Bromosucinamide 6
Describe Mechanism of following reactions
Oppenneuroxidation ii) Birch reduction 8
OR
Describe mechanism of following reactions
Fries migration ii) MPV reduction 6
Write two applications for each of the following
Sodium periodate ii) Seleniumoxide iii) Perchloric acid 6