FACULTY OF PHARMACY
B. Pharmacy 2/4 II-Semester (Non-CBCS)(Backlog) Examination, December 2018
Subject Pharmaceutical Organic Chemistry II
Time 3 Hours Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 Explain the mechanism of Nitration and Sulphonation in Benzene.
Explain the Nucleophillic substitution in Halobenzenes.
OR
Explain acidity of phenols.
Write the structure and electrophilic substitution reactions of Anthracene.
2 Write in detail about Conformational isomerism with examples.
What is racemic modification? How do you resolute racemic modification.
OR
Discuss cis-trans isomerism with examples.
Define and explain Elements of symmetry.
3 Write a note on Fischer indole synthesis.
Discuss the Electrophillic aromatic substitution reactions of Pyridine.
OR
Write any two methods of synthesis of thiophene.
Discuss the Oxidation reactions of Quinoline and Isoquinoline.
4 Outline the method of preparation and important reactions of Pyrazole.
Write the structure and specific uses of drug compounds containing.
Phenam Cepham Oxazine
OR
Outline the method of preparation and chemical reactions of Isoxazole.
Write the structure and specific uses of drug compounds containing
Thiazole Diazine Oxazole
5 Write two applications for each of the following:
Selenium oxide Lead tetra acetate N-Bromosucinamide
Describe mechanism of following reaction
Oppenneur oxidation MPV reduction
OR
Explain birch reduction and Arndt-Eistert synthesis.
Mention two applications of LAH.