FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2017
PATHOLOGY
PAPER IV

POSSESSION USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.
Time 3 hours PATH/D/17/32/IV
Max. Marks 100
Important instructions:
• Attempt all questions in order.
• Each question carries 10 marks.
• Read the question carefully and answer to the point neatly and legibly.
• Do not leave any blank pages between two answers.
• Indicate the question number correctly for the answer in the margin space.
• Answer all the parts of a single question together.
• Start the answer to a question on a fresh page or leave adequate space between two
answers.
• Draw table/diagrams/flowcharts wherever appropriate.
Write short notes on:
1. Recent diagnostic criteria for multiple myeloma.
Clinical use of hematopoietic growth factors
5+5
2. Genetic basis of hypercoagulability
Utility of peripheral smear evaluation in era of hematology
automation
5+5
3. Describe fibrinolysis and discuss hyperfibrinolytic states
Pathogenesis and diagnosis of paroxysmal nocturnal
hemoglobinuria.
5+5
4. Etiopathogenesis of pure red cell aplasia
Role of hepcidin in diagnosis of iron disorders.
5+5
5. Normal human hemoglobins
Laboratory diagnosis of anti-phospholipid syndromes
5+5
6. Peripheral blood and bone narrow findings in Hairy cell
leukemia and its variants
Antenatal screening for hemolytic disease of new born
5+5
7. Automated reticulocyte parameters and their use in hematology
Congenital morphological anomalies of leucocytes.
5+5
8. Laboratory evaluation of peripheral blood lymphocytosis in a 68
years old male patient.
Harmful effects of stored blood transfusion
5+5
9. Pathogenetic classification of platelet function defects
Laboratory monitoring of antithrombotic drugs
5+5
10. Mixed phenotype acute leukemia
Laboratory investigations in a case of red cell fragmentation
syndrome
5+5