FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
JUNE 2018

POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE EXAMINATION HALL.
PATHOLOGY
PAPER-IV
PATH/J/18/32/IV
Time: 3 hours
Max. Marks:100
Important Instructions:
Attempt all questions in order.
Each question carries 10 marks.
Read the question carefully and answer to the point neatly and legibly.
Do not leave any blank pages between two answers.
Indicate the question number correctly for the answer in the margin space
Answer all the parts of a single question together.
Start the answer to a question on a fresh page or leave adequate space between two answers.
Draw table/diagrams/flowcharts wherever appropriate.
Write short notes on:

1. Biochemical basis of megaloblastic anaemia.
Pathogenesis of anaemia of chronic disorders.
5+5
2. Flow cytometric evaluation of chronic lymphoproliferative
diseases.
Qualitative defects of platelets and their diagnosis.
5+5
3. Diagnostic criteria of multiple myeloma
Indications and interpretation of bone marrow trephine
biopsy.
5+5
4. Hemophagocytic syndromes
Lab findings and diagnostic criteria in antiphospholipid
antibody syndrome.
5+5
5. Prognostic factors of acute lymphoblastic leukemia
Enumerate tyrosine kinase receptor mutations in chronic
myeloproliferative disorders.
5+5
6. Molecular pathogenesis of β thalassemia.
Classification and laboratory findings in immune haemolytic
anaemia.
5+5
7. Indications for use of blood components.
Immunological transfusion reaction.
5+5
8. Causes and diagnostic approach to neutropenia.
Apheresis
5+5
9. Laboratory findings in hairy cell leukemia.
Pathology pathophysiology of acquired thrombotic
thrombocytopenic purpura.
5+5
10. Genetic basis of hemochromatosis.
Pathogenesis of myelodysplasia.
5+5