IHan Ticket
Department of Animal Sciences
ENTRANCE EXAMINATION, February 2013 Ph. D Animal Sciences Time: 2 hours Maximum Marks: 75

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All questiOns carry one mark each. Answer all, or as many as you can.
0.33 mark will be deducted for every wrong answer.
There are a total .of 10'pages in this question paper. Answer sheet will be
provided separately. Check this before you start answering.
ThequestionpaperconsistsofPartAand PartB. Themarksobtained inPartA wiUbe taken in consideration in case of a tie i.e., when more than one student gets equal marks, to prepare the merit list.


PART "A"
1.
Which one Qf the following enzymes is crucial for a cell to ensure equal supplies of oxaloacetate and Acetyl-CoA for citric acid biosynthesis?

2.
Fastidious microorganisms are those which grow fast under in vitro conditions require special conditions for growth cannot be grown under in vitro grow only in the presence of light


. "
Citrate synthaSe Isocitrate dehydrogenase
Pyruvate carboxylase Aconitase

conditions
3. How many amino acid residues'are present perturnofa-helix?
2.6 4.5 3.6 5.4

2
4. Which one of the following techniques is used to detect the localization of the maternal mRNAs in developing embryo?
Northwestern hybridization In situ hybridization
Northern blotting qRT-PCR

s. Organ transplantation between two individuals with identical HLA alleles at all loci can be described as
Autograft Syngenic graft
Allograft. Heterograft

6.
Deficiency of copper affects the formation of collagen by reducing the activity of

Glycosyl transferase Galactosyl transferase
Lysyl hydroxylase Lysyl oxidase


7.
Which parasitic infection produces Ablastin antibody?


Leishmania donovani Trypanosoma lewisi
Plasmodium species Chilomastix species

8. The first organisms to evolve were

Primitive eukaryotes Aerobic bacteria
Anaerobic bacteria Photosyntheitc bacteria

9.
The amount of MgCh required for the preparation of 1 L of a 5 mM solution is

598mg 952 mg
476mg 1.196 g


10.
Following compounds are capable of forming hydrogen bonds with water except:


Methanol Methyl acetate
Acetamide Hexane


diffusible signaling molecule that plays protein that facilitates totipotency
a role during morphogenesis
protein that mediates cell-cell diffusible signaling, molecule that induces
interactions distinct cellular responses based on its
local concentration

12. The amino acid residue present most abundantly in water soluble globular protein is
Serine Histidine
Isoleucine Lysine


13.
In India, maximum biodiversity is observed at

Western Himalayas Eastern Ghats Western Ghats North East Himalayas

14.
Genes that segregate with maleness

Polygenic Holandric
Epistatic Pleiotropic


15.
Which one of the following would be affected by antiviral drug that act by inhibiting viral DNA polymerase?


Cytomegalovirus Influenza virus
Mumps virus Measles virus
16. Sickle-cell trait in humans is a classic example of
Selection against receSSIve Selectionfor recessivehomozygotes. homozygotes Selection for heterozygotes Selection against heterozygotes

17. Shortage of acetylcholine in brain is associated with
A) Parkinson's disease Alzheimer's disease Huntington's disease Schizophrenia
18.
Which one of the following classes of RNA characteristically contains unusual purines and pyramidines?

tRNA rRNA
mRNA 16s RNA


19.
What is the pH of a solution where the x 10-4 mollL?


8.6 9.6
10.6 11.6

20.
Electro Mobility Shift Assay is used to detect

Nucleoprotein interactions DNA-DNA interactions RNA-RNA interactions Protein-protein interactions

21.
Which one of the following organelles is involved in apoptosis?


Ribosomes Endoplasmic Reticulum Peroxisomes Mitochondria

22.Theexposure of DNA to S-bromouracil results in
Replacement of the AT base pair to Deletion of thymine, causing
CG by pairing with guanine frameshift mutation
Base pairing with adenine and Thymine dimer forrration
causes no change in the daughter
s during replication

23 lVhen lacl gene is deleted in E. coli, the expression levels of p-galactosidase in this mutantwould be
negligible several fold higher than in an normal
E. coli strain
significantly increased after the significantly decreased after the
addition of lactose addition of lactose

24. Actin lilaments and microtubules share all of the following properties except
they are involved in cell motility they are intrinsically polar structures
they associate with motor proteins they are assembled from subunits that
are heterodimers

25. Which one of the following isiotan autoimmune disease?
Rheumatoid arthritis Type I Diabetes mellitus
Graves disease FmPhYsema

PART
26. The primary RNA transcript of the chicken ovalbumin is 7700 nucleotides long but the mature RNA encodes only for 624 amino acids. This dilference in size is primarily due to
removal of poly-A tail mRNA splicing
cleavage of polycistronic sequences mRNA cleavage

27. *Nosocomial' infection is
hospital acquired life+hreatening
not so serious related to the nasopharynx

2S,"Pneumococctts" is a nick name for
Legianellapneumophila Staphylococcus pneumophila
Streptococcus pneumoniae Mycoplasma pneumoniae

29.[rELISA, the substrate for alkaline phosphatase is
p-nitophenyl phosphate BCIP only
o-nitrophenyl phosphate BCIP and NBT

r.
30.
When compared with unphosphorylated protein in SDS-PAGE, the phosphorylated protein migrates at

Faster rate Slower rate Same rate Cannot be detected

31.
The rate of reaction catalyzed by the enzyme carbonic anhydrase is

106 molecules ofC02 per second 105 molecules ofCOzper second 107 molecules ofC02 per second 108 molecules ofCOzper second

32.
Thrombin catalyzes the hydrolysis of peptide bonds between

Arg-Gly Lys-Arg Trp-Tyr Tyr-Phe

33.
The metal ion present in alcohol dehydrogenase enzyme is



34.
A reaction occurs spontaneously only if 4G is negative. Such reaction is known as

Endergonic Exergonic Spontaneous Chemical

35.
In glucose metabolism, lactate dehydrogenase reduces pyruvate to lactate while oxidizing

NADH to NAD+ FADH2 to FAD+ FAD+ to FADH2 NAD+ to NADH

36.
The peptide bond length between -CO and -NH group is


1.45 AO 1.32 AO 1.54 AO 1.23 AO
37. Cell surface marker used for identification of myeloid cell populations during flow
cytometric analysis is
CD4 CD11b CD8 CD19
38. Anti-MUllerian hormone causes
Mullerian ducts to develop Wolffian ducts Testes to produce testosterone into MUllerian apoptosis Wolffian ddeferens ducts ucts to to deve regress lop into by Vas


D 3

39.
Which one of the following molecules present the antigen peptides following viral infection?

ToIl like receptor MHCI
MHCII Fc receptor


40.
When the growth of a bacterium necessitates the addition of a particular substance in the medium, the microorganism is called

Heterotroph Autotroph
Auxotroph .D) Prototroph


41.
Transmission of cyclosporiasis occurs by

Person to person Fecal oral route
Respiratory route Sexual transmission


42.
Most of the DNA viruses assemble and bud from

Nucleus Cytoplasm
Golgi apparatus Endoplasmic reticulum


43.
Aspergillus infections are usu!llly seen in

Skin Mouth
Lungs GI tract


44.
Vasopressin plays an important role in

Milk secretion Renal water absorption
GH secretion Adrenal steroidogenesis


45.
Which one of the following is most virulent of all mycotic pathogens?


Nistoplasma capsulatum Blastomyces dermatitidis
Coccidioides immitis Candida albicans

46.
A bacterium containing sodium ions at a concentration of 0.1 mM lives in a pond that contains sodium ions at 0.005 mM. Evidently, sodium ions are entering the cell by

Active transport Endocytosis
Diffusion Osmosis


47.
Contaminated food and water is a common mode of infection for


Ascaris lumbricoides Wuchereria bronchofti
Ancylostomaduodenale Leishmania donovani



48. Which one of the following ligands is involved in platelet adhesion and aggregation?
Fibronectin Laminin
ICAM Interleukin

49. Retroviruses replicate by integrating into the host genome
forming an intermediate double­directly
stranded DNA
independently replicating in the host

elaboration of RNA-dependent RNA cytoplasm using reverse
polymerase activity for duplicating its transcriptase genetic material.
50.
Statocyst, a balancing organ commonly seen in aquatic animals, is absent in

Bivalves Cephalopods
Sea Urchins Fishes


51.
Which one of the following statements is false with respect to mammalian p450 enzymes?


They are involved in phase I All of them are flavoproteins
metabolism of xenobiotics
Primarily localized -in smooth

Liver contains highest amount but endoplasmic reticulum and
found in most other tissues
mitochondria
52. Mutation of recombination activating genes, Rag-lor Rag-2, results in a block of B cell development at
Pre-B stage
Pre-Pro-B stage
Pro-B stage

B cell stage
53.
Dietary deficiency of cobalamine causes

Rickets Scurvy
Pernicious anemia Pellagra


54.
Wilson disease is caused due to mutation in


Fibroblast growth factor receptor LDL receptor
Glc NAc phosphotransferase

Copper-dependent ATPase
55. Following is a common enzymatic marker for plasma membrane
ATP synthase Sialyl transferase ATPase Galactosyl transferase

D-·£3

56.
Adenylyl cyclase activity is inhibited by

Glucagon Calcitonin
Acetylcholine Insulin


57.
Rickets is caused by nutritional deficiency of

Tocopherol Calcipherol
Riboflavin Niacin


58.
Which of the following minerals function as prosthetic group in enzymes?

Cobalt, copper and sodium Copper, selenium and sodium
Cobalt, copper and selenium Selenium, cobalt and sodium


59.
Remodeling of connective tissue matrix involves aU of the foUowing except

Tryptase Cathepsin G
Heparin Carboxypeptidase


60.
The primary function of chemokine, IL-8 is to

Promote influx of leukocytes Activate eosinophils Increase vascular permeabili!y Affect basophil growth and differentiation

61.
The following is!Y!1. an example for integrin.

CD49d LPAM-I
LFA-l CD62E


62.
Which one of the foUowing membranes would be the most fluid?


A bilayer made of lipids with A bilayer made of lipids with polyunsaturated 18 carbon-fatty saturated 18 carbon-fatty acids acids
A bilayer made of lipids with A bilayer made of lipids with polyunsaturated 16 carbon-fatty saturated 16 carbon-fatty acids acids
63. The half-life of radioisotope esS] is
8.7 days 87 days
164 days 14 days
64. Taxol is a cytoskeletal drug that acts by
stabilizing microtubule Stabilizing free tubulin
Stabilizing actin monomers Stabilizing actin filaments

65.
Which one of the following membrane lipids is absent in prokaryotes?

Phospholipids Glycolipids
Cholesterol Diacylglycerol phosphate


66.
The sugar moiety important for targeting acid hydrolases from the Golgi complex to Iysosomes

Mannose-6-phosphate Glucose-6-phosphate
Ribose-6-phosphate Galactose-6-phosphate


67.
Activation of a gene is marked by


Bj Iviethyiation
Phosphorylation Myristoylation


68.
Which one of the following is not an autosomal recessive disorder in human?

Phenylketonuria Tay Sachs Disease
Ptosis Cystic fibrosis


69.
Epiboly occurs during

Fertilization . Neurulation
Cleavage Gastrulation


70.
Which one of the following is sex influenced trait?

Beard development Pattern Baldness
Masculine musculature Color blindness


71.
5-methyl cytosine substitutions are common as they Deaminate to thymidine Deaminate to uracil


Mispair with adenine parent and daughter strands
72.
A mechanism that can cause a gene to move from one linkage group to another is

Inversion Duplication
Deletion Translocation


73.
Which one the following is a lymphoid lineage?


Mast cells NK cells
Neutrophils Platelets


74. The theory of population genetics and evolution includes all except
Mating must be random Mutation is the source of genetic
variation
There is no influx of genes from No genotype has selective advantage
other populations over another

75. The canonical signature motif of amino acid sequence required for export of proteins from nucleus is
-Leu-Ala-Leu-Lys-Leu-Ala-Gly­B) -Pro-Pro-Lys-Lys-Lys-Arg-Lys-Val Leu-Asp-Ile -Lys-Asp-Gly-Leu-COO· -Ser-Lys-Leu-COO·
For rough work




3.
Discuss Louis Althusser's interpretation ofMarxism.

4.
Write a short research proposal on a hypothetical research question.


START ANSWERING FROM HERE
QUESTION NO. II (Marks: 15)
Write short-note on any THREE ofthe following. All the questions carry equal marks.

1.
New ethnography

2.
Experimental research methods

3.
Culture and personality

4.
Qualitative research methods

5.
Srinivas' concept of 'dominant caste'

6.
Different levels of sociocultural integration by Julian Steward


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