B. Pharmacy 2/4 I-Semester (Supplementary) Examination, April 2018
Subject Pharmaceutical Organic Chemistry I
Time 3 Hours Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 Explain SP, SP2 and SP3 hybridizations with suitable examples.
Define the terms
Dipole moment Bond angle
Molecular orbitals and give their significance in organic chemistry
OR
Explain Inductive effect Enantiomerism and diastereomerism
Resonance giving suitable examples
Explain energy diagrams of reactants and products during the course of the
reaction.
2 Explain Markovnikov's and AntiMarkovnikov's addition with suitable examples.
Explain electrophilic addition in alkynes and conjugated dienes.
OR
Write a note an stereochemistry of cyclohexane. Write the structure of chair
conformation showing axial and equatorial bonds.
Explain Bayer's strain theory.
3 Write any three general methods to prepare hydorxy (alcoholic) compounds.
Write mechanism, kinetics and stereochemistry involved in SN1 and SN2
reactions.
OR
Write mechanism involved in E1 and E2 eliminations.
explain Saytzeff rule and Hofmann rule.
Explain Williamson's synthesis of ethers.
4 Explain any four methods of preparation and reactivity of Carbonyl compounds.
Write any five important nucleophilic addition reactions which you have studied.
OR
Write any three general methods to prepare Carboxylic acids.
Explain why trichloroacetic acid is more acidic than dichloro and which in turn
more acidic than monochlorocetic acid.
Write two applications each for Diethylmalonate and Ethylacetoacetate.
5 Explain basicity in aliphatic and aromatic amines.
Write any three reactions of amines.
Write the Hinsberg's method of separation of amines.
OR
Write different methods of preparation of Nitro compounds.
Explain the different reactions and synthetic utility of aryl diazonium salts.