FACULTY OF PHARMACY
B. Pharmacy 2/4 I-Semester (Suppl) Examination, April 2018
Subject: Pharmaceutical Organic Chemistry I
Time: 3 Hours Max. Marks: 70
Note: Answer All Questions. All Questions carry Equal Marks.
1. What is Hybridization? Discuss SP1, SP2 and SP3 Hybridization with suitable
examples 8
Write a note on Electrometaric effect and polarity of molecules 3+3
OR
What is activation energy. Explain the energy diagram of reactants and products
during reaction 1+7
Explain the terms with examples chirality and Hydrogen bonding
Define the terms configuration and conformation. Write the various conformations of
cyclohexane and discuss their stability. 10
Add a note on peroxide effect. 4
OR
Explain the markonikovs and antimarkonikovs addition with examples 7
Write the general methods to prepare the alkenes.
Discuss in detail the mechanism and stereo chemistry involved in SN1 and SN2
reaction 14
OR
Add a note on Ziesel method or Williamson synthesis 6
How do you distinguish between primary, secondary and tertiary alcohols with
different chemical reagents. 8
Explain in detail the acidity of carboxylic acids with examples. 7
Write any two method for preparation of aldehydes and Ketones. 7
OR
How do you synthesize the Schiffs bases 6
Discuss any two Hydrophillic addition reactions of carbonyl compounds with
mechanisms 8
Write any two methods to synthesize secondary amines 6
Give the mechanism for any two of the following reactions 8
Sandmayer reaction
Coupling reaction
Gattermann reaction
OR
Give reactions of amines. 7
Write the synthesis and applications of aryl diazonium salts. 7