FACULTY OF PHARMACY
B. Pharmacy 2/4 I-Semester (Non-CBCS) (Backlog) Examination, November 2018
Subject Pharmaceuticals Organic Chemistry I
Time 3 Hours Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 Explain the following terms with examples. (4x3.5)
Hydrogenbonding Electromeric effect
Chirality Hybridization
OR
What is activation energy? Discuss the energy diagrams of reactants and
products during the course of reaction.
What is isomerism? Explain structural and spatial isomerism with example.
2 Explain Mrkonikov's and Antimarkonikovs addition with examples.
Write any two methods of preparation of alkanes.
OR
Explain the stability of cycloalkanes by different theories.
Write any two chemical reactions of alkanes.
3 Discuss in detail the mechanism and stereochemistry involved in SN1 and
SN2 reactions.
Write a note on hydrogen bonding in alcohols.
OR
How will you distinguish between primary, secondary and tertiary alcohols with
different chemical reagents?
Write a note on Sayetzaffs rule.
4 Write any three methods to synthesize carboxylic acids.
Discuss the reactivity and applications of malomic acid ester.
OR
How do you synthesize schiffs bases?
Write any two methods each to prepare aldehydes and ketones.
5 Write a note on basicity of amines.
Give the mechanism for following reactions (3x3.5)
Sand Neyer reaction
Coupling reaction
(iii)Gattermann reaction
OR
Explain separation of amines by Hinsberg's method.
Write a note on Aryldiazonium sats
Write any two methods to prepare Nitroalkanes.