FACULTY OF PHARMACY
B. Pharmacy 2/4 I-Semester (Main) Examination, November 2018
Subject Pharmaceutical Organic Chemistry I
Time 3 Hours Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 What is hybridization? Discuss Sp1, Sp2 and Sp3 hybridizations with suitable
examples.
Discuss the following with suitable examples.
(A)Molecular orbitals Polarity of molecules Covalent bond
OR
Explain the following with suitable examples
Resonance Mesomeric effect Inductive effect
What is activation energy? Discuss the energy diagrams of reactants and products
during the course of the reaction.
2 Write any three general methods to prepare alkenes.
Explain Markovnikov's and anti- Markovnikov's addition of alkenes.
(iii)Write a note on acidity of alkynes.
OR
Discuss the following:
Bayer's strain theory
Cis-trans isomerism
(iii)Configuration and conformations
3 Discuss SN1 and SN2 reactions with mechanism and stereochemistry.
How do you distinguish primary, secondary and tertiary alcohols?
(iii)Write about Walden inversion.
OR
Explain E1 and E2 elimination reactions with mechanism and stereochemistry.
Explain Saytzeff's rule.
(iii)Write any two methods for synthesis of ethers.
4 Write any three nucleophilic addition reactions of carbonyl compounds with
mechanism.
Write two methods each to prepare aldehydes and ketones.
OR
Write synthetic applications of Diethyl malonate and Ethyl acetoacetate.
Explain acidity of Carboxylic acids.
(iii)Write any two methods to prepare carboxylic acids.
5 Write any three methods of synthesis of nitroalkanes.
Write about basicity of amines.
Explain Hinsberg's method of separation of amines.
OR
Write synthesis and applications of aryldiazonium salts.
Give reaction of amines with Nitrous acid, alkylation and acylation.
(iii)How do you differentiate primary, secondary and tertiary amines?