FACULTY OF PHARMACY
B. Pharmacy 4/4 I Semester (Suppl.) Examination, April 2017
Subject: Medicinal Chemistry II
Time: 3 Hours Max.Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 Define and classify local anaesthetics. 7
Write the synthesis, mode of action and uses of pethidine and lidocaine. 4+3
OR
Write the SAR of para amino benzoic acid derivatives. 7
Write a note on morphine and its analogues. 7
2 Write in detail about alkylating agents. 7
Write a note on aminoglycoside antibiotics. 7
OR
Write the SAR of penicillins. 7
Write a note on tetracyclines. 7
3 Classify antiviral agents and write the synthesis of zidovudine. 7
Write a note on antifungal agents. 7
OR
Write the life cycle of malarial parasite and describe the 8-aminoquinolines used in
malaria. 4+3
Outline the synthesis, mode of action and IUPAC nomenclature of chloroquine and
pyrimethamine. 3+4
4 Write a note on benzodiazepines. 7
Outline the synthesis, nomenclature of diazepam, phenobarbitone. 4+3
OR
Write a note on antiparkinsonism agents. 7
Write a note on hydantoins. 7
5 Discuss biochemical role of water soluble vitamins and their prophylactic and
therapeutic uses. 7
Write in brief about essential amino acids. 7
OR
Write a note on development of protein drugs. 8
Explain the biochemical role of any two fat soluble vitamins. 6