FACULTY OF PHARMACY
B. Pharmacy 4/4 I Semester (Main) Examination, November 2017
Subject Medicinal Chemistry II
Time 3 hours Max. Marks 70
Note Answer all questions. All questions carry equal marks.
1 Write the classification of NSAID's 7
Describe the SAR of Para amino benzoic acid derivatives used as local
anaesthetics. 7
OR
Classify narcotic analgesics with examples. 7
Write the SAR of morphine analogues. 7
2 Write the classification of antineoplastics and outline the synthesis of
methotrexate. 5+2
Write the classification and mode of action of sulphonanides. 5+2
OR
Classify Betalactum antibiotics and outline the synthesis of ampicillin. 5+2
Write in detail about quinolone antibacterials. 7
3 Write a note on Antileprotic agents. 7
Classify antitubercular drugs and write the synthesis and mode of action of
INH. 7
OR
Write in detail about 4-amino quinolines used in malaria. 7
Write the synthesis and IUPAC of metronidazole, and primaquine. 3.5+3.5
4 Define and classify the sedatives and hypnotics with examples. 7
Outline the synthesis, mode of action, IUPAC nomenclature and uses of
phenobarbitone and Diazepam. 3+4
OR
Write a note on hydantoins used as anticonvulsants. 7
Write a note on the SAR of Barbiturates. 7
5 Write the structure and biochemical role of fat soluble vitamins. 7
Write in brief about "Essential amino acids". 7
OR
Write a note on development of protein drugs. 7
Describe the biochemical role of any two water soluble vitamins. 7