FACULTY OF PHARMACY
B. Pharmacy IV/IV I Semester (Non-CBCS) (Main) Examination, November 2018
Subject: Medicinal Chemistry II
Time: 3 Hours Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1. Define for NSAIDs and classify them with minimum two structural examples.
Write the structure, synthesis and uses of the following drugs.
Bupivacaine Piroxicam
Explain the SAR of Pethidine analogues.
OR
Write a short note on Narcotic antagonists.
Write the structure, synthesis and uses of the followings.
Diclofenac Fentanyle
Explain in detail about the SAR of local anaesthetics.
2. Write the classification of Antineoplastic agents.
Write a note on quinolone antibiotics.
Write the synthesis and mode of action of following drugs.
Sulphamethoxazole Chlorambucil
OR
Define antibiotics and write the general classification of antibiotics with suitable
examples.
Write a short note on Amino glycoside antibiotics.
Write the structure, synthesis, mode of action and uses of chloramphenicol.
3. Explain the life cycle of Malaria parasite and write the classification of anti Malarial
agents.
Write the structure, IUPAC name, mode of action and uses of the following
Zidovudine (ii)INH 8+6
OR
Enumerate the various classes of antifungal agents with examples.
Write the synthesis and mode of action of the following drugs.
Chloroquine Piperazine citrate
Contd..2..
Library
G.Pulla Reddy College of Pharmacy
HyderabadOU 1701 OU 1701
Code No. 13055 Non-CBCS

4. Outline the classification of anticonvulsants.
Write in detail about SAR of Benzodiazepines.
Write the synthesis and uses of the following drugs
Imipranine Ketanine
OR
Define Sedatives and Hypotics and classify them with suitable examples.
Write a note on Antiparkinsonism drugs. 7+7
5. What are Vitamins? Write the source, storage, biochemical role of fat soluble
vitamins. 7+7
Write in detail about development of protein drugs.
OR
Explain in detail about essential amino acids and their functional role.
Write the structure, uses and biochemical role of following Vitamins. 8+6
Vitamin B1
Vitamin C
Vitamin E