FACULTY OF PHARMACY
B. Pharmacy 4/4 I Semester (Suppl.) Examination, April 2018
Subject: Medicinal Chemistry II
Time: 3 Hours Max.Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 Define local anesthetics and classify them with minimum two examples. 6
Write the synthesis, mode of action and uses of the following drugs.
Lidocaine ii) Ibuprofen 4
Write in detail about structural modification of morphine analogues. 4
OR
What are narcotic analgesics. Classifs them with structural examples. 6
Write the synthesis, mode of action and uses of the following drugs.
Fentanyl ii) Paracetamol 4
Explain in detail about the SAR of pyrazolidine dione derivatives. 4
2 Define Beta lactan antibiotics and explain the classification and mode faction of
penicillins. 7
What are antibacterial agents? Write the structure, synthesis, mode of action and
uses of any one sulphonamide drug. 7
OR
Write a note on cephalosporins. 7
Write the synthesis, mode of action and uses of the following drugs:
Ampicillin ii) 5-Fluronzacil 9
3 Define antiviral agents and write their mode of action and classification. 7
Write a note on anti-tubercular agents. 7
OR
Write the synthesis, mode of action and uses of the following drugs: 7
Pyrimethanine ii) Dapsone
Write a note on antileptotic agents. 7
4 Define general anesthetics and explain the various stages of anesthesia. Write the
classification of general anesthetics. 8
Write the structure, mode of action and uses of the following:
Phenytion ii) Diazepam 6
OR
Define tranquillizers and write their classification. 8
Write the structure, synthesis, mode of action and uses of the following:
Carbanazepine ii) Amitryptaline 6
5 What are essential amino acids? Write their chemical structure and biochemical role. 8
Write the sources, uses and biochemical role of following vitamins.
Vitamin B6 ii) Vitamin D iii) Vitamin B2 6
OR
Explain in detail about protein drug development. 9
What are vitamins? Explain the source, storage, biochemical role of vitamins A K. 5