FACULTY OF PHARMACY
B. Pharmacy 4/4 I Semester (Main) Examination, November 2017
Subject Dosage Formulation and Design (Pharmaceutics III)
Time 3 hours Max. Marks 70
Note Answer all questions. All questions carry equal marks.
1 Explain in detail about preformulation studies with respect to the dosage form
necessities and physical and chemical properties. 14
OR
What are the different pathways of degradation of pharmaceutical products
and how they can be protected from degradation? 7
Write a short note on accelerated stability testing. 7
2 Explain about different factors to be considered in the design of sustained
release dosage forms. 8
Discuss the preparation of encapsulated slow release granules for the
sustained release. 6
OR
Write the importance of microencapsulation. Write a note on air suspension
technique. 7
Write a note on spray drying and spray congealing. 7
3 Enumerate the advantages of TDDS and give examples of marketed TDDS.
Explain in detail about in-vitro evaluation methods of TDDS. 14
OR
Explain about Pilo 20, Pilo 40 and erodable inserts. 7
Write the applications of liposomes. Explain about physical dispersion of
liposomes. 7
4 Write in detail about various approaches for enhancement of bioavailability of
drugs. 14
OR
Explain in detail about bioequivalence protocol for conducting bioequivalence
study. 14
5 Differentiate QA and QC. Explain briefly about active or therapeutic materials
control. 7
Explain the quality assurance at the startup. 7
OR
What are the records that must be maintained to control and assure the
manufacturing practices? 7
Write a note on raw materials controls and control products. 7