FACULTY OF PHARMACY
B. Pharmacy 4/4-Year I-Semester (Suppl.) Examination, April 2018
Subject Dosage Formulation and Design (Pharmaceutics III)
Time 3 Hours Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 What are preformulation studies? Explain different powder characteristics and
their effect on formulation. 14
OR
Explain about accelerated stability studies. 7
Describe hydrolysis, oxidation and polymerization effect on formulation and its
stability. 7
2 Explain the formulation methods of Sustained Release Dosage Forms (SRDF)
and their evaluation. 14
OR
Define microencapsulation and explain the following techniques.
Air Suspension ii) Coacervation Phase separation iii) Spray Congealing
iv) Solvent evaporation
3 Write a note on preparation and evaluation methods of liposomes. 14
OR
Describe about preparation, evaluation and applications of nanoparticles.
4 Define absolute and relative bioavailability. Explain about experimental design
of bioequivalence studies. 14
OR
Explain about process validation methods. 7
Describe the statistical interpretation of data in bioequivalence studies. 7
5 Write about sources of quality variation. 7
Explain active and therapeutic material control. 7
OR
Describe the concept of statistical quality control and quality control charts. 7
Explain in detail about manufacturing control, packing and label control for
various pharmaceutical products. 7