FACULTY OF PHARMACY
B. Pharmacy 2/4 I-Semester (Suppl.) Examination, April 2016
Subject Pharmaceutical Organic Chemistry I
Time 3 Hours Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 What is isomerism? Explain structural and spatial isomerism with examples.
Explain
Inductive effect, Mesomeric effect Resonance with suitable examples.
OR
Explain SP1, SP2 and SP3 hybridization.
Discuss the following with suitable examples
Polarity Solubility Inter molecular forces
2 Write the general methods of preparation of alkynes.
Explain peroxide effect Kharasch effect in electrophilic addition reactions.
(iii)Write a note on the free radical reactions of alkanes.
OR
Explain the following:
Sachse Mohr theory
Baeyer's strain theory
(iii)Cis-trans isomerism
3 Give any three methods to synthesize alkyl halides.
Explain E1 and E2 elimination reactions with mechanism.
Write the differences between Nucleophilic substitution Vs Elimination.
OR
Discuss SN1 and SN2 reactions with mechanism and stereochemistry.
Write about oxidation of alcohols.
(iii)Write Williamson's synthesis of ethers.
4 Write any three methods each to prepare Ketones and aldehydes.
Discuss any two named nucleophilic addition reactions of carbonyl compounds
with mechanism.
OR
Write any three general methods of preparation of carboxylic acids.
Write synthetic applications of any acetoacetic ester.
Explain mechanism involved in the hydrolysis of acid derivatives.
5 Write any three important reactions of amines.
Explain separation of amines by Hinsberg's method.
(iii)Write the significance of Sand Meyer's reaction.
OR
Write synthesis and applications of aryldiazonium salts.
Give any three methods to prepare nitroalkanes.
(iii)How do you differentiate primary, secondary and tertiary amines by chemical
reactions?