FACULTY OF PHARMACY
Pharm D I Year (Main Backlog) Examination, July 2018
Subject: Pharmaceutical Organic Chemistry
Time: 3 Hours Max.Marks: 70
Note: Answer all questions from Part A. Any Five questions from Part B.
PART A (10x2 20 Marks)
1 Write the IUPAC name of the following:


3 2
O O
CH C-CH C-OH


3 2 3
CH3 Br
CH CH C H-CH -CH
2 Give the structural formula of:
But-1-en-3-yne
1-Bromo-2-chloro ethane
3 Define the term acidity and basicity.
4 Explain polarity of molecules with example.
5 Explain activating and deactivating groups with example.
6 Arrange the following in decreasing order of their reactivity.
Benzene, Toluene and Nitrobenzene.
7 What is resonance? Give any two example.
8 Write any one method of preparation of lactic acid.
9 Explain hydrogen bonding with example.
10 Explain the acidity of phenol.
PART B (5x10 50 Marks)
11 Explain in detail the mechanism, stereochemistry and rearrangement reaction of
SN1 with suitable example. 6
Explain the mechanism of free radical reaction of methane. 4
12 Explain the nucleophilic addition reactions of aldehyde. 5
Describe the methods of preparation of acid derivatives. 5
13 Write short notes on the following:
Reimer Tieman's reaction 5
Williamson's synthesis 5
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Library
G.Pulla Reddy College of Pharmacy
HyderabadOU 1701 OU 1701
Code No. 4253

14 Write the mechanism of:
Benzoin condensation 5
Reformatsky reaction 5
15 Write the "test for purity" and uses for tartaric acid and glyceryl trinitrate. 10
16 Give 3 methods for the preparation of cyclopropane. 5
Explain in detail about bimolecular displacement mechanism. 5
17 Explain the mechanism of sulphonation reaction of benzene. 5
Explain in detail the effect of halogen on electrophilic aromatic substitution in alkyl
benzene. 5
18 Write the preparation and assay method of vanillin and dimercaprol. 5
Write the principle involved in the assay of aspirin. 5