FACULTY OF PHARMACY
Pharm. D YDC) I-Year (Instant) Examination, March 2018
Subject Pharmaceutical Organic Chemistry
Time 3 Hours Max. Marks: 70
Note: Answer all questions from Part answer any five questions from Part-B.
PART A (10 x 2 20 Marks)
1 Define electrophile with examples.
2 Write the structural formula for the following:
2-ethyl -1-methyl butane
2 hydroxyl-4-pentanone
3 Define Baye's strain theory.
4 Why chlorobenzene undergoes electrophonic?
5 Why acetic acid is stronger than ethanol?
6 Write the structure and medicinal uses of the following:
Dimercaprol Lactic acid
7 Why phenols are much more acidic than alcohols?
8 Write about Wittig Reaction.
9 Describe the various rules governing Resonance.
10 Define free radicals with examples.
PART B x 10 50 Marks)
11 Define free radical substitution reaction. Explain the mechanism of halogenations of
alkanes.
12 Explain a note on E1 and E2 mechanism.
13 Explain the following:
Markovinikov's addition
Free radical addition
14 Explain in detail about acyl substitution reaction with four examples.
15 Describe the mechanism and stereochemistry of SN
1 reaction.
16 Write the reaction and mechanism of
Cannizaro reaction
Reformatsky reaction
17 Write the structure, preparation, assay and uses of the following:
Asprin
Saccharin sodium
18 Explain the following:
Basicity of amines
Benszoin condensation