FACULTY OF PHARMACY
B. Pharmacy 2/4 I Semester (Main) Examination, October 2016
Subject: Pharmaceutical Organic Chemistry I
Time: 3 Hours Ma x.Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 Explain the energy diagrams of reactants and products during the course of reaction. 5
Write a note on following:
Hybridization ii) Melting point iii) Boiling point 9
OR
Add a note on polarity of molecules. 5
Define the terms with examples
Inductive effect ii) Cis-trans isomerism iii) Resonance 9
2 Discuss the free radical mechanism for the chlorination of methane. 7
Write any four methods of preparation of alkanes. 7
OR
Discuss the importance of Bayer's strain theory. 7
Explain the reactions of alkenes. 7
3 How do you prepare ethers by Williamsons synthesis? 7
Write a note on Sayetzaff's rule. 7
OR
Discuss about mechanism of nucleophillic substitution reactions. 7
Write any two methods for synthesis of alcohols. 7
4 Write the general reactions of carbonyl compounds. 7
Write any two methods of preparation of aldehydes. 7
OR
Discuss the reactivity and applications of malonic acid ester. 7
Write any two methods of synthesis of carboxylic acids. 7
5 Write any two methods for synthesis of nitroalkanes. 7
Write a note on aryldiazonium salts. 7
OR
Write a note on basicity of amines. 6
How do you differentiate between primary, secondary and tertiary amines with
chemical reactions? 8